Importantly, the manipulating of mitochondrial dynamic is significant for the progresses of breast cancer. These advanced studies established the roles of mitochondrial fission and fusion of breast cancer in the metabolism, proliferation, survival, and metastasis. ResultsĮligible studies ( n = 19) were evaluated and discussed in the systematic review. MethodsĪll related studies were systematically searched through online databases (PubMed, Web of Science, and EMBASE) using keywords (e.g., breast cancer, mitochondrial, fission, and fusion), and these studies were then screened through the preset inclusion and exclusion criteria. The advanced literature about the crucial role of mitochondrial dynamics in breast cancer is performed. Mitochondrial dynamics, which are involved in mitochondrial fusion and fission, are regulated by specialized proteins and lipids, and their dysregulation causes human diseases, such as cancer. Under extracellular stimulation, mitochondria undergo constant fusion and fission to meet different cellular demands.

Mitochondria play critical roles in cellular physiological activity as cellular organelles.